11-(Piperazin- or homopiperazin-1-yl)-5H-imidazo-(2,1-C)(1,4)benzodiazepines useful as anti-allergics

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United States of America Patent

PATENT NO 4686219
SERIAL NO

06827849

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Abstract

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Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxyl, nitro, amino, cyano, methylsulfonamido, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 3 carbon atoms, (alkyl of 1 to 3 carbon atoms)thio or (alkanoyl of 2 to 4 carbon atoms)amino; R.sub.3 is hydrogen, fluorine, chlorine, bromine or alkyl of 1 to 3 carbon atoms; R.sub.4 is hydrogen, alkyl of 1 to 4 carbon atoms, hydroxy(alkyl of 2 to 4 carbon atoms), (alkoxy of 1 to 2 carbon atoms)-(alkyl of 2 to 4 carbon atoms), alkenyl of 3 to 6 carbon atoms, alkynyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, (cycloalkyl of 3 to 7 carbon atoms)-(alkyl of 1 to 3 carbon atoms) or (unsubstituted or substituted phenyl)-(alkyl of 1 to 3 carbon atoms) where the substituent is fluorine, chlorine, bromine, methyl, methoxy, hydroxyl or trifluoromethyl; and n is 1 or 2; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antiallergic.

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Patent Owner(s)

Patent OwnerAddress
BOEHRINGER INGELHEIM KG A CORP OF GERMANYD-6507 INGELHEIM AM RHEIN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fugner, Armin Gau-Algesheim, DE 16 201
Schneider, Claus Ingelheim am Rhein, DE 63 383
Walther, Gerhard Bingen, DE 40 284
Weber, Karl-Heinz Gau-Algesheim, DE 56 423

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