Antibacterial penem derivatives
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United States of America Patent
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-
Aug 4, 1987
Issued Date -
N/A
app pub date -
Apr 2, 1985
filing date -
Jul 8, 1981
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Penem-derivatives of the formula I ##STR1## in which R is hydrogen or a carboxyl esterifying group R.sup.1 is phenyl, naphthyl, thienyl, pyridyl, quinolyl or isoquinolyl any of which is optionally substituted by one, two or three substituents of the group halogen, cycloalkyl, --NH.sub.2, --CONH.sub.2, --NO.sub.2, --CN, --R.sup.2, --OR.sup.2, --SR.sup.2, --SO--R.sup.2, --SO.sub.2 R.sup.2, --CO--R.sup.2, --CO--O--R.sup.2, --CH.sub.2 --CO--O--R.sup.2, --NHR.sup.2, --NR.sup.2 R.sup.2', --CO--NH--R.sup.2, --CO--NR.sup.2 R.sup.2', --NH--CO--R.sup.2, --NH--CO--NH--R.sub.2, --NH--CO--NH--R.sup.2, --NH--SO.sub.2 --R.sup.2, --CF.sub.3, --CO--OH, --CO.sub.2 --CO--OH wherein R.sup.2 and R.sup.2' are the same or different and each represents alkyl of 1 to 4 carbon atoms or a salts thereof, process for the manufacture thereof and antibacterial pharmaceutical preparations containing them.
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