Urea stabilized with a lactone in various pharmaceutical and cosmetic preparations
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United States of America Patent
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Jun 9, 1987
Grant Date -
N/A
app pub date -
Jul 3, 1985
filing date -
Jul 3, 1985
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A pharmaceutical preparation containing 1 to 50% urea and 0.05 to 30% of a lactone is disclosed. A preferred lactone is gamma-butyrolactone which is preferably present in an amount of about 0.05 to 0.1 part by weight per 1 part by weight of urea. The lactone stabilizes the urea with respect to various parameters including changes in pH. The pharmaceutical preparation may be any preparation with stabilized urea such as a skin lotion or cream used to moisturize skin, or a post surgical preparation because urea aids in debridement, dissolves coagulum and promotes epithelialization. Alternatively the preparation may be an injectable solution used in the treatment for mobilization of edema fluid, as urea is used for an osmotic diuretic.
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