Process for obtaining complex FVIII/vWF of therapeutical use and resulting products
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United States of America Patent
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Jun 2, 1987
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N/A
app pub date -
Sep 18, 1985
filing date -
Sep 18, 1984
priority date (Note) -
Expired
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Abstract
The invention relates to a process for producing FVIII/vWF complexes for therapeutical use possessing both haemophilic A activity and Willebrand activity as well as a high degree of purity, such process substantially comprising the steps of fixing the FVIII/vWF complex in physiological conditions on a particular monoclonal antibody and releasing said complex by means of a suitable elution medium having no effct on the functions of the FVIII/vWF complex but able to dissociate the bonds linking the selected monoclonal anitbody to the FVIII/vWF complex, then collecting the latter in a highly purified form.
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