Importance

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Abstract

Disclosed are a 2-phenylalkyl-3-aminoalkyl-4(3H)-quinazolinone compound of Formula (1): ##STR1## wherein, X represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a phenoxy group, a benzyloxy group, a halogen atom or a hydroxy group; Y represents an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a benzyloxy group, a halogen atom or a nitro group; R.sup.1 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms; R.sup.2 represents an alkyl group having 1 to 5 carbon atoms or a group of Formula (2) ##STR2## [wherein, Z represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms or a halogen atom; d is an integer of 1 to 3; and l is an integer of 1 to 5]; or R.sup.1 and R.sup.2 represent together with the nitrogen atom to which they are attached, a cyclic amino group of the formula: ##STR3## [wherein, A represents an alkylene group having 2 to 6 carbon atoms or a group of the formula --(CH.sub.2).sub.2 --O--(CH.sub.2).sub.2 --]; a and b are independently an integer of 1 to 3; and n and m are independently an integer of 1 to 5, or a pharmaceutically acceptable acid addition salt thereof, a process for preparing said compound, a composition comprising said compound as an active ingredient and a method of treatment by use of said compound. The compounds of the present invention have calcium antagonistic, vasodilative, and antihypertensive activities.

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First Claim