Process for preparing hydratropic acids and esters thereof, from propiphenones
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United States of America Patent
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May 19, 1987
Grant Date -
N/A
app pub date -
May 3, 1985
filing date -
May 16, 1984
priority date (Note) -
Expired
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Abstract
A process for preparing hydratropic acids and the esters thereof, of formula Ar--CH(CH.sub.3)--COOR where R=H or lower alkyl and Ar=phenyl possibly substituted. This process consists in reacting on the propiophenones of formula ArCOCH.sub.2 CH.sub.3, a chlorinating or brominating agent, an alcohol R'OH where R'=lower alkyl, an orthoester R.sub.1 --C(OR').sub.3 wherein R.sub.1 =H or lower alkyl, and metal zinc; then possibly hydrolyzing the esters obtained. With this process can be prepared hydratropic acids known for their anti-inflammatory activity.
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