Support for solid-phase oligonucleotide synthesis
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United States of America Patent
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Apr 21, 1987
Grant Date -
N/A
app pub date -
Nov 1, 1985
filing date -
Nov 1, 1985
priority date (Note) -
Expired
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Abstract
This invention relates to a support for oligonucleotide synthesis and more particularly to a necleoside-linker/polymer support composite having the general formula P'--S' wherein P' is a polymer support which bears oxirane, aziridine or episulfide groups or which contains good leaving groups for nucleophilic displacement; and S' is a nucleoside-linker having the general formula W--(CH.sub.2).sub.a --X--(CH.sub.2).sub.b --Y--(CH.sub.2).sub.c --Z wherein W and Z each independently comprise a nucleophile; X and Y which, independently may or may not be present, comprise groups of high hydrophilicity; and a, b, c are integers from 0 to 9, wherein a plus b plus c exceeds 6.
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