Derivatives of glycerophosphocholine and glycerophosphoethanolamine, their preparation and their use
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United States of America Patent
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Nov 11, 1986
Grant Date -
N/A
app pub date -
May 13, 1985
filing date -
May 15, 1984
priority date (Note) -
Expired
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Abstract
The invention relates to new triphenylmethyl derivatives of sn-glycero-3-phosphocholine and sn-glycero-3-phosphoethanolamine of the general formula ##STR1## in which T denotes a triphenylmethyl group which is unsubstituted or monosubstituted or polysubstituted by C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy or halogen, and the radicals R.sub.1, R.sub.2 and R.sub.3 either are identical and each represent a methyl group, or are different, in which case two of the radicals R.sub.1, R.sub.2 and R.sub.3 always denote hydrogen, and the third radical represents a triphenylmethyl group which is unsubstituted or monosubstituted or polysubstituted by C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy or halogen, a process for their preparation, and their use for the preparation of chemically defined pure enantiomeric 1,2-diacyl-sn-glycero-3-phosphocholines and 1,2-diacyl-sn-glycero-3-phosphoethanolamines which are substituted in positions 1 and 2 of the glycerol, independently of one another, by different acyl radicals.
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