Phosphoaziridine compounds useful for treatment of tumors
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United States of America Patent
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Oct 14, 1986
Grant Date -
N/A
app pub date -
Apr 12, 1982
filing date -
Apr 12, 1982
priority date (Note) -
Expired
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Abstract
Novel phosphoaziridines of the formula: ##STR1## wherein Z is oxygen or sulfur, R.sub.1 is independently at each occurrence H or --CH.sub.3, R.sub.2 is independently at each occurrence --CH.sub.3 or nitrophenyl R.sub.5 ; R.sub.3 is --NHR.sub.4, --OR.sub.4, --SR.sub.4 or ##STR2## where R.sub.4 is a radical containing up to 30 atoms including at least one amine, ester, ether, alkyl, substituted alkyl, hydrogen, phenyl, substituted phenyl, carbamate, heterocyclic ring or R.sub.5 group; provided that, when R.sub.4 contains and R.sub.5 group, R.sub.4 has an alkyl group between the phosphorous and the R.sub.5 group; and R.sub.5 is a radical containing and electron affinic group comprising a quinone, or a heterocyclic or phenyl ring directly connected to a radical selected from the group consisting of nitro, nitroso, sulfinyl, sulfoxine, and N-oxide; provided that the compound contains at least one R.sub.5 radical and provided that when R.sub.1 is H, the R.sub.2 group on the same ring is R.sub.5 ; and the method for using the above compounds for the treatment of tumors.
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