Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
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United States of America Patent
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Aug 12, 1986
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N/A
app pub date -
Dec 18, 1984
filing date -
Mar 6, 1984
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Abstract
Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is a pyrimidin-2-yl ring and the other is a 4 carbon chain attached to a p-fluorophenyl ring at the terminal carbon. The terminal carbon of this butylene chain is also bonded to an oxygen atom as part of a carbonyl, carbinol, or ketal functionality. These compounds possess psychotropic properties, particularly atypical antipsychotic activity of good duration. By virtue of pre-clinical pharmacological testing, these compounds appear useful as potential antipsychotic agents which lack the typical movement disorder side-effects of standard antipsychotic agents.
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