1-aryloxypropanolamines
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United States of America Patent
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Jun 10, 1986
Grant Date -
N/A
app pub date -
Jul 15, 1985
filing date -
Jul 25, 1984
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Disclosed are novel compounds having the formula ##STR1## wherein R.sub.1 is a hydrogen or halogen atom, a lower alkyl, lower alkoxy, lower alkoxy lower alkyl, lower alkenyl, lower alkenyl oxy, cyano, hydroxy, trifluoromethyl, nitro, amino, aminocarbonylmethyl, lower monoalkylamino, lower dialkylamino group; R.sub.2 is a hydrogen or halogen atom, cyano, lower alkyl or lower alkoxy or acylamino group; R.sub.3 is a hydrogen or halogen atom, a lower alkyl or lower alkoxy group, while R.sub.2 and R.sub.3 together can also be a butadienyl or methylene dioxy group; R.sub.4 is a hydrogen atom or a lower alkyl group; R.sub.5 is a chlorine atom or a trifluoromethyl group; X is an alkylene group; and the non-toxic, pharmaceutically acceptable acid addition salts thereof. The compounds are suitable for treatment and prophylaxis of hypertension.
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