Transdermal systemic dosage forms
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United States of America Patent
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Apr 29, 1986
Grant Date -
N/A
app pub date -
Apr 12, 1983
filing date -
Apr 12, 1983
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Sustained release dosage forms that provide transdermal delivery of drugs utilizing the skin as the rate controlling membrane for the drugs. Methods for producing the dosage forms are also disclosed. The dosage forms are laminates produced by heating a laminate to a glass transition temperature of an outer removable layer of the laminate. While maintaining the laminate at the glass transition temperature, a vacuum is applied to draw the laminate into a suitable shape for a drug reservoir. An aqueous solvent is added to the reservoir and a semipermeable barrier layer is placed over the aqueous solvent in the reservoir. A pharmaceutically active drug is contained in the aqueous reservoir and this drug moves transdermally to provide the active ingredient to the patient.
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