Aryloxypropanolamine derivatives, pharmaceutical compositions and adrenegic thereof
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United States of America Patent
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Apr 1, 1986
Grant Date -
N/A
app pub date -
Jan 6, 1984
filing date -
Jan 21, 1983
priority date (Note) -
Expired
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Abstract
Compounds having general formula I ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, lower alkoxy, alkyl enoxy, halogen, cyano, carboxyamido or ureido group optionally separated from the phenyl ring by a methylene or ethylene bridge; R.sub.2 is hydrogen, halogen, lower alkyl or alkoxy; R.sub.3 is hydrogen, halogen, lower alkyl, lower alkoxy or R.sub.2 and R.sub.3, taken together, are a methylendioxy group; R.sub.4 is hydrogen or lower alkyl, endowed with remarkable cardioselective .beta.-adrenolytic properties, are described. The process for their preparation and pharmaceutical compositions containing them are also described.
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