Derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same
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United States of America Patent
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Jan 21, 1986
Grant Date -
N/A
app pub date -
Apr 24, 1984
filing date -
Apr 29, 1983
priority date (Note) -
Expired
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Abstract
New derivatives of chenodeoxycholic, ursodeoxycholic, cholic and ursocholic bile acids having in the side chain in the 19 position a cyclopropane ring are described together with taurine and glycine conjugated derivatives thereof. The compounds of the invention, prepared from suitable olephinic intermediates by reaction with alkyl diazoacetates or by Simmons-Smith reaction and optional conjugation with taurine or glycine, are endowed with interesting therapeutic properties.
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