Trinitroglycerol sustained release vehicles and preparation therefrom
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United States of America Patent
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Sep 17, 1985
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N/A
app pub date -
Aug 16, 1983
filing date -
Jul 8, 1981
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Expired
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Abstract
A trinitroglycerol-containing substantially disaccharide-free polymeric diffusion matrix is provided for the transdermal systemic delivery of trinitroglycerol through the skin of a patient. The polymeric diffusion matrix contains sufficient trinitroglycerol to be released over a prolonged period of time and comprises a first lower molecular weight, partially hydrolyzed polyvinylalcohol component, a second higher molecular weight, essentially fully hydrolyzed polyvinylalcohol component, and glycerol.
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