Antimicrobially effective derivatives of phenol and methods for their production

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United States of America Patent

PATENT NO 4532367
SERIAL NO

06412851

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Abstract

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A method is provided for the production of antimicrobially effective phenol derivatives according to general Formula I in which R.sub.1 is bromine or chlorine, R.sub.2 is methyl or ethyl, R.sub.3 is hydrogen or sodium, potassium, ammonium or by alkyl with up to 10 C-atoms substituted ammonium, magnesium, calcium, barium, aluminum, tin, bismuth, copper, zinc, R.sub.4 and R.sub.5 are independently hydrogen, alkyl or alkoxy with up to 5 C-atoms, bromine or chlorine. The compounds are obtained by benzylation of 6-halogen- or 4-halogen-2-alkylphenol, halogenation of 2-alkyl-4-benzylphenol or -6-benzylphenol, or by alkylation of 6-halogen-4-benzylphenol or of 4-halogen-6-benzylphenol and if necessary through reaction of the product with hydroxide, alcoholate, carbonate or hydrogen carbonate of the above-mentioned metals. Water or lipid soluble effective substances are obtained which display a broad antimicrobial activity spectrum.

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Patent Owner(s)

Patent OwnerAddress
JENAPHARM GMBH & CO KGOTTO-SCHOTT-STRASSE 15 07745 JENA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Grubel, Gerhard Jena, DD 1 1
Kramer, Axel Greifswald, DD 31 295
Schrotter, Eberhard Rangsdorf, DD 1 1
Teubner, Herbert Wernigerode, DD 2 8
Weuffen, Wolfgang Greifswald, DD 3 34

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