Polymer-metal complexes containing quaternary nitrogen atoms used in the treatment of hypercholesteremia

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United States of America Patent

PATENT NO 4528184
SERIAL NO

06438487

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A novel polymer-metal complex containing quaternary nitrogen atoms, which is obtained by subjecting polyethylenepolyamine or polyethyleneimine to a reaction with a bifunctional compound represented by the formula Y--A--Z wherein Y and Z are same or different and are --CH.sub.2 X, --CH(OH)CH.sub.2 X or ##STR1## group, respectively, A is a single bond, --(CH.sub.2).sub.m --, --CH.sub.2 --O--CH.sub.2 -- or --CH.sub.2 --O--(CH.sub.2).sub.k --O--CH.sub.2 --group, X is chlorine, bromine or iodine atom, m is an integral of 1 to 3, and k is an integral of 1 to 4, and then subjecting the resulting cross-linked polymer to a coordination of a polyvalent metal ion, a salt thereof, a process for the preparation thereof and a pharmaceutical agent comprising the same.

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Patent Owner(s)

Patent OwnerAddress
KABUSHIKI KAISHA VITAMIN KENKYUSYO2134-1 MITAKE AZA-HIRASHIBA KANI-GUN GIFU-KEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Iida, Takafumi Kasugai, JP 9 151
Ishiwata, Yoshiro Nagoya, JP 22 83
Kurono, Masayasu Nagoya, JP 73 682
Kuwayama, Meiji Nagoya, JP 1 19
Nakagawa, Osamu Nagoya, JP 43 748
Ogasawara, Tomio Nagoya, JP 11 158

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