Process for preparing N-benzyloxycarbonyl-L-aspartic acid
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United States of America Patent
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May 21, 1985
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N/A
app pub date -
Aug 26, 1983
filing date -
Aug 26, 1983
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Expired
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Abstract
N-Benzyloxycarbonyl-L-aspartic acid (Z-Asp) is synthesized by adding benzyl chloroformate to a solution of L-aspartic acid and sodium hydroxide at temperatures from about 5.degree.-55.degree. C. and over a wide pH range of about 9.2 to 13.8 in the presence of a surfactant and/or a buffer and then acidifying the reaction mixture. Carrying out the reaction in the presence of a surfactant reduces cycle time, while maintaining a high yield with low by-product content. The buffer prevents wide fluctuations in pH and minimizes localized reaction. These conditions are desirable when the reaction rate has been increased by addition of a surfactant or an increase in temperature of the reaction mixture.
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