Importance

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Abstract

Compounds of the formula ##STR1## wherein R.sup.1 is a C.sub.1-8 alkyl group or a C.sub.3-7 cycloalkyl group; R.sup.2 is a C.sub.1-6 alkyl group or a C.sub.3-7 cycloalkyl group; R.sup.3 is a hydroxy group or a group of formula --OR.sup.4 or --OCOR.sup.5 where R.sup.4 is an alkyl or alkenyl group which may contain up to 6 carbon atoms (or such a group substituted by halogen, C.sub.1-6 alkoxy, carboxyl, phenyl, phenyl substituted by nitro, halo, C.sub.1-4 alkoxy or C.sub.1-4 alkyl), a C.sub.3-7 cycloalkyl group, a phenyl group (or such a group substituted by nitro, halo, C.sub.1-4 alkoxy or C.sub.1-4 alkyl), or a carbon-attached 5-7 membered heterocyclic ring in which the hetero atom is selected from nitrogen, oxygen and sulphur, and R.sup.5 is a hydrogen atom or a group R.sup.4 as defined above; and the D-homo analogues thereof having the group --CO.sub.2 R.sup.2 (wherein R.sup.2 is as defined above) at the 17a.beta.-position, and salts thereof have activity as antidysrhythmic agents and may be applicable for the treatment of dysrhthmias in humans or animals. The compounds may be provided in the form of compositions in admixture with pharmaceutical carriers or excipients and may be prepared by a variety of processes known for producing steroids of this type. The invention also provides intermediates for the preparation of compounds of formula (I), in which intermediates R.sup.1 and/or R.sup.2 is replaced by a hydrogen atom, and processes for the preparation of such intermediates.

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First Claim