Amidine derivatives with anti-complement activity
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United States of America Patent
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Jan 29, 1985
Grant Date -
N/A
app pub date -
Apr 21, 1982
filing date -
Apr 28, 1981
priority date (Note) -
Expired
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Abstract
Amidino compounds represented by the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsin, antiplasmin, antikallikrein and antithrombin agents. Having strong anti-Cl activity and anti-complement activity, they are also useful as anti-complement agents. These amidino compounds are prepared by reacting carboxylic compounds represented by the formula R.sub.1 --COOH or their reactive intermediates with amidinonaphthol represented by the formula ##STR2## and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof.
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