Antihypertensive isoindole derivatives
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United States of America Patent
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Jan 22, 1985
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N/A
app pub date -
Nov 12, 1982
filing date -
Nov 12, 1982
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Expired
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Abstract
Novel phthalimide intermediates are reduced to 5-sulfamoyl-6-halo-3-oxoisoindole compounds bearing a substituted 1-phenylalkyl-4-piperidinyl moiety as the isoindole N-substituent. Preferred compounds such as 6-chloro-2,3-dihydro-3-oxo-2-[1-(phenylmethyl)-4-piperidinyl]-1H-isoindole-5-sulfonamide exhibit diuretic and antihypertensive properties.
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