Methods of stabilizing thimerosal in presence of polyvinylpyrrolidone
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United States of America Patent
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Jul 17, 1984
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app pub date -
Jun 22, 1983
filing date -
Jun 22, 1983
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Abstract
A method of preparing solutions containing thimerosal and polyvinylpyrrolidone which results in improved stability of thimerosal is disclosed. The method involves applying a certain amount of heat to the polyvinylpyrrolidone while it is in aqueous solution and prior to its combination with thimerosal. The required thermal input to the polyvinylpyrrolidone solution is a function of four variables: solution temperature, heating time, external pressure and polyvinylpyrrolidone concentration. Advantageously this method may be employed in the manufacture of contact lens solutions.
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