Absorption-promoting compounds, compositions thereof with pharmaceuticals and/or bases for rectal administration and method of use
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United States of America Patent
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Apr 10, 1984
Grant Date -
N/A
app pub date -
Mar 24, 1981
filing date -
Nov 9, 1980
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Compounds satisfying four specific requirements, namely: (1) a log P value in the range of from 2.5 to 6, (2) a molecular structure with at least one carboxyl group, (3) a pKa value for the carboxyl group of not less than 2.5 and (4) absence of halo substitution, and nontoxic salts thereof promote absorption of pharmacologically-active substance through the rectum into the bloodstream and are effective to raise the concentration of such active substance in the bloodstream even when the active substance is usually unabsorbable or absorbable through the rectum only with considerable difficulty. The compounds are combined with pharmacologically-active ingredients, with pharmaceutical bases suitable for rectal administration of drugs and with appropriate combinations of both.
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