Process for the removal of the formyl group from N-formyl peptides and esters thereof
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United States of America Patent
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Feb 28, 1984
Grant Date -
N/A
app pub date -
Apr 26, 1982
filing date -
May 13, 1981
priority date (Note) -
Expired
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Abstract
A process for the removal of the formyl group in N-formylated peptides or their esters is described. The N-formyl compound is reacted with hydrazine or a substituted hydrazine of formula I: ##STR1## at a pH between 1 and 3.5, keeping the pH constant during the reaction. The process is particularly useful for the preparation of aspartam.
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