N-Substituted aziridine-2-carboxylic acid derivatives and their immuno-stimulation compositions and methods

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United States of America Patent

PATENT NO 4410532
SERIAL NO

06334614

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Abstract

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A 2-cyanaziridine derivative of the formula ##STR1## wherein R' is a straight-chained or branched, saturated or mono- or polyunsaturated aliphatic hydrocarbon radical with up to 8 carbon atoms, which is substituted by an aromatic nitrogen-containing heterocyclic radical with 5 or 6 ring-members and 1, 2 or 3 nitrogen atoms optionally substituted by halogen, alkoxy with up to 8 carbon atoms, alkyl with up to 8 carbon atoms, hydroxyl, carbalkoxy with up to 9 carbon atoms, carbamoyl, dialkylamino the alkyl moieties of which having up to 8 carbon atoms, cycloalkylamino, the cycloalkyl moiety having 3-10 carbon atoms, acetylamino, nitro, cyano, acetyl, alkylthio with up to 8 carbon atoms, alkylsulphinyl with up to 8 carbon atoms, alkylsulphonyl with up to 8 carbon atoms, sulphamoyl, phenyl, trifluoromethyl, phenoxy, acetoxy or methylenedioxy; or a pharmacologically acceptable salt thereof, exhibits immune stimulating activity.

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Patent Owner(s)

  • BOEHRINGER MANNHEIM GMBH

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berger, Herbert Mannheim, DE 12 74
Bicker, Uwe Mannheim, DE 14 153
Bosies, Elmar Weinheim, DE 32 657
Grafe, Alfred Morlenbach, DE 3 11
Kampe, Wolfgang Heddesheim, DE 43 602

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