Oxytocin derivatives
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United States of America Patent
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Sep 6, 1983
Grant Date -
N/A
app pub date -
Feb 27, 1981
filing date -
Mar 24, 1980
priority date (Note) -
Expired
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Abstract
New oxytocin derivatives having an inhibitory effect on uterine contractions, pharmaceutical compositions containing the oxytocin derivatives, and use of the derivatives in the production of medicines are described. The derivatives are 1-deamino-(2-O-alkyltyrosine)-oxytocin of the formula ##STR1## wherein Mpa is a 3-mercaptopropionyl residue and X is an alkyl group having 2-4 carbon atoms, preferably an ethyl group. Apart from their inhibitory effect on vasopressin and oxytocin induced uterine contractions, the new oxytocin derivatives are capable of inhibiting the spontaneous contraction pattern of the uterus.
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