Semi-synthesis of human insulin

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United States of America Patent

PATENT NO 4401757
SERIAL NO

06336072

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Abstract

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A process for preparing B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on a lysine carbonyl in peptide bondings and produced by Achromobacter lyticus M 497-1.

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Patent Owner(s)

Patent OwnerAddress
SHIONOGI & CO LTDOSAKA 541-0045

International Classification(s)

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  • 1981 Application Filing Year
  • C12R Class
  • 137 Applications Filed
  • 0 Patents Issued To-Date
  • 0 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances19810255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Masaki, Takeharu Ibaraki, JP 3 19
Morihara, Kazuyuki Osaka, JP 8 52
Oka, Tatsushi Osaka, JP 5 39
Soejima, Masami Tsuchiura, JP 3 19

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  • 4 Citation Count
  • C12R Class
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  • 42 Age
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