Semi-synthesis of human insulin

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United States of America Patent

PATENT NO 4400465
SERIAL NO

06336071

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Abstract

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A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide bondings.

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Patent Owner(s)

Patent OwnerAddress
SHIONOGI & CO LTDOSAKA-SHI OSAKA 541-0045

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Morihara, Kazuyuki Osaka, JP 8 52
Oka, Tatsushi Osaka, JP 5 39
Tsuzuki, Hiroshige Hirakata, JP 13 108

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