Preparation of biocompatible materials by immobilization of apyrase
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United States of America Patent
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Aug 2, 1983
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N/A
app pub date -
Dec 28, 1981
filing date -
Aug 1, 1979
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Abstract
A prosthetic polymer material is made non-thrombogenic by immobilizing apyrase on its surface. Immobilization is preferably carried out by hydrolytically activating the surface of a polyamide polymer or a polyethylene terphthalate polymer, and treating the hydrolyzed polymer with a solution of cross-linking agent and a solution of apyrase. The apyrase converts adenosine diphosphate to adenosine monophosphate and adenosine whereby the formation of thrombi is inhibited.
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