Process for the synthesis of isosorbide mononitrates
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United States of America Patent
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Apr 26, 1983
Grant Date -
N/A
app pub date -
Feb 16, 1982
filing date -
Feb 27, 1981
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to the synthesis of isosorbide mononitrates. The process according to the invention consists in reacting a hydrazine derivative with isosorbide dinitrate, in a polar solvent medium. The reaction is preferably carried out at the reflux temperature of the solvent medium, with an excess of the hydrazine derivative. A preferred solvent medium is a mixture of tetrahydrofuran and methanol. The process leads to the preferential formation of isosorbitol-2-mononitrate, which is a coronary vasodilator.
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