Method for the cold sterilization of preparations containing blood coagulation factor VIII
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United States of America Patent
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Jan 25, 1983
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N/A
app pub date -
Sep 8, 1981
filing date -
Sep 10, 1980
priority date (Note) -
Expired
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Abstract
A process for the cold sterilization of a preparation containing blood coagulation factor VIII, comprising (A) contacting a protein solution containing factor VIII with a physiologically compatible, non-ionogenic tenside, and then subjecting the solution to (B) irradiation with ultraviolet light, (C) treatment with beta-propiolactione, and (D) to an adsorption treatment with colloidal silica, steps B-C-D being performed in the sequence B-C-D, B-D-C, D-C-B or D-B-C.
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