Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation

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United States of America Patent

PATENT NO 4366145
SERIAL NO

06277980

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Abstract

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A stable ergot alkaloid soft gelatin capsule consisting essentially of a soft gelatin capsule shell and encapsulated therein a liquid center fill solution consisting essentially of a therapeutically effective amount of an ergot alkaloid of the formula ##STR1## wherein R.sub.1 is hydrogen or halogen, R.sub.2 is hydrogen or C.sub.1-4 alkyl, R.sub.3 is isopropyl, sec.-butyl, isobutyl or benzyl, R.sub.4 is methyl, ethyl or isopropyl, and either R.sub.5 is hydrogen and R.sub.6 is hydrogen or methoxy or R.sub.5 and R.sub.6 together is an additional bond, or mixtures thereof, dissolved in a pharmaceutically acceptable polar, hydrophilic soft gelatin capsule center fill solvent.

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Patent Owner(s)

Patent OwnerAddress
NOVARTIS PHARMACEUTICALS CORPORATIONONE HEALTH PLAZA EAST HANOVER NJ 07936

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jacobs, Allen L Randolph, NJ 1 8
Kornblum, Saul S Springfield, NJ 2 18
Stoopak, Samuel B West Caldwell, NJ 2 18

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