Method for the quantitative determination of plasminogen activators
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United States of America Patent
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Jul 14, 1981
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N/A
app pub date -
Sep 11, 1979
filing date -
May 28, 1976
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Expired
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Abstract
The present invention relates to a method for the quantitative determination of enzymes in human and mammal body fluids and tissue extracts, using a substrate which has the structure R.sup.1 --X--Y--Z--NH--R.sup.2 wherein X represents a group having the formula ##STR1## in which R.sup.3 is a straight or branched alkyl radical having 1 to 7 carbon atoms or a cyclohexyl or cyclohexylmethyl radical, Y represents a seryl group or a group having the formula --NH--(CH.sub.2).sub.n --CO-- in which n is an integer from 1 to 7, Z represents an arginyl or lysyl group, R.sup.1 represents hydrogen or an acyl or sulfonyl group and R.sup.2 represents an aromatic hydrocarbon radical which optionally may carry substituents. The method includes measuring by photometric, spectrophotometric or fluorescence-photometric methods the quantity of the split product NH.sub.2 R.sup.2 formed by the hydrolytic action of the biologically active factors on the substrate.
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