Geldanamycin derivatives and antitumor drug
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United States of America Patent
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Apr 14, 1981
Grant Date -
N/A
app pub date -
Jan 3, 1980
filing date -
Feb 19, 1979
priority date (Note) -
Expired
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Abstract
Geldanamycin derivatives the following formula ##STR1## wherein R.sup.1 represents a saturated alkylamino which should have at least two carbon atoms, an unsaturated alkylamino, a substituted lower alkylamino, cycloalkylamino, pyrrolidino or aralkylamino group or methoxy group; R.sup.2 represents hydrogen atom, a halogen atom or a lower mono or dialkylamino; when R.sup.1 is methoxy group, R.sup.2 is a halogen atom or lower alkylamino group, or ##STR2## and Geldanamycin derivative is 8,9-epoxy-Geldanamycin. The compounds are effective as antitumor drugs.
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