Process for preparing pure 2-methyl-3-(.beta.-hydroxyethylcarbamoyl)quinoxaline 1,4-di-N-oxide, and other compounds similar thereto
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United States of America Patent
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Oct 14, 1980
Grant Date -
N/A
app pub date -
Mar 8, 1979
filing date -
Nov 24, 1978
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Expired
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Abstract
The present invention provides a process for preparing high purity 2-methyl-3-(.beta.-hydroxyethylcarbamoyl)quinoxaline 1,4-di-N-oxide, generally involving the following stages carried out separately and in succession: (a) reacting benzofuroxane with an acetacetic acid ester of formula CH.sub.3 --CO--CH.sub.2 --COOR, in the presence of a catalyst in the form of ethanolamine, and in a suitable solvent; (b) separating and isolating the reaction product formed under (a), e.g., 2-methyl-3-(methylcarboxylate)-quinoxaline-1,4-di-N-oxide; and (c) reacting the compound described under (b) with an excess of ethanolamine over the stoichiometric quantity, to give the final carbamoyl derivative.
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