Stable aqueous solutions of glucans and glucan derivatives capable of inhibiting sarcoma in mice

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United States of America Patent

PATENT NO 4207312
SERIAL NO

05654452

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Abstract

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The glucans and glucan derivatives which inhibit the growth of sarcoma 180 in mice are only sparingly soluble in water, and their aqueous solutions are unstable. In the presence of 0.1 to 1.0 g/dl water soluble dextran, hydroxyethyl starch, carboxymethyl cellulose, or polyethylene glycol, they form relatively concentrated and stable solutions, particularly in the presence of hexoses, pentoses or sugar alcohols having 5 or 6 carbon atoms.

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Patent Owner(s)

  • AJINOMOTO CO., LTD.;MORISHITA PHARMACEUTICAL CO., LTD.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fujii, Mitsuharu Ageo, JP 3 47
Hamuro, Junji Tokyo, JP 44 491
Iwao, Yutaka Urawa, JP 1 19
Kuoka, Tatsuo Iwatsuki, JP 1 19
Setsuta, Tatsuo Tokyo, JP 1 19
Shiio, Tsuyoshi Kamakura, JP 5 25
Yoshihama, Takashi Yokohama, JP 1 19
Yugari, Yasumi Kamakura, JP 7 78

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