HIGH-THROUGHPUT ASSAY FOR CELL MIGRATION, CHEMOTAXIS, AND FUNCTION
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United States of America
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Apr 10, 2025
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Jan 26, 2023
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Jan 26, 2023
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Abstract
An assay system permits study of cell migration through tissue-relevant extracellular matrices under a chemokine gradient within a modular assay platform. Activated CD3+ T-cells were detected, quantified, and studied as they migrated towards chemokines (CXCL10 and CXCL12) and chemokine mimetics (CXCR3 agonist) using the assay system. Discovery of drugs, and the study of microenvironments, stimuli, and responding cells are facilitated by the assay system.
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