SYSTEM AND METHOD FOR ANTIMICROBIAL SUSCEPTIBILITY TESTING
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United States of America
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Apr 10, 2025
app pub date -
Oct 7, 2024
filing date -
Oct 7, 2024
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Abstract
A method for performing antimicrobial susceptibility testing, comprising activating protein biosynthesis in microorganisms obtained from a biological sample in an acclimatization buffer; exposing the microorganisms to a library that includes various antimicrobials at predetermined concentrations, wherein exposure either kills the microorganisms or blocks protein biosynthesis in the microorganisms that are sensitive to one or more of the antimicrobials at one or more of the predetermined concentrations; labeling newly biosynthesized proteins produced by the microorganisms that survive exposure to the antimicrobials with a non-canonical amino acid (ncAA); tagging the labeled proteins with a detectable element attached to the ncAA, to create an amount of detectable signal; and comparing the amount of detected signal to a positive control, wherein an absence of or a decrease in the amount of signal relative to the positive control indicates effectiveness of one or more of the antimicrobials at one or more of the predetermined concentrations.
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