GENERATION OF BROWN ADIPOCYTES FROM HUMAN PLURIPOTENT STEM CELLS
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United States of America
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Apr 10, 2025
app pub date -
Feb 1, 2023
filing date -
Feb 1, 2023
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Abstract
Provided herein are methods of generating Gata6-positive brown adipose progenitor cells, and brown adipose cells and tissue therefrom. Additionally, provided herein are methods of generating UCP1 positive organoids. Generally, the methods include a step of culturing brown adipose progenitor cells in a medium containing an FGF signaling pathway activator, a BMP signaling pathway activator, a TGFβ activator, a Wnt inhibitor, and a thyroid hormone receptor activator.
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