HYDROGEL COMPOSITION, METHOD FOR PRODUCING THE SAME, AND USE THEREOF FOR STEM CELL MIMETIC PEPTIDE SUPPLEMENTATION
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United States of America
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Issued Date -
Apr 10, 2025
app pub date -
Apr 27, 2023
filing date -
Apr 27, 2023
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Abstract
A method of preparing a hydrogel or spray composition comprising the steps of mixing a low viscosity diluent mix with a lyophilized protein mix to make a precursor solution on site just prior to application, mechanically mixing the precursor solution, and then adding an initiator mix to form a hydrogel. The hydrogel composition can include a broad-spectrum protein mix comprising at least one of a plurality of growth factors including bFGF, EGF, GDF-11, HGF, KGF, PDGF-AA, TGF-b1, and VEGF. The initiator mix can comprise at least one selected from the group consisting of a pH modifier, a photoinitiator, and a free radical initiator. The pH modifier can be selected from the group consisting of triethanolamine, NaOH, KOH, and sodium bicarbonate. The precursor solution can further comprise at additive including at least one selected from the group consisting of amino acid stabilizer, humectant, preservative, emollient, and anti-aging ingredients.
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