SYSTEMS AND METHODS FOR PROVIDING CARDIAC PULMONARY NERVE STIMULATION
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United States of America
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Issued Date -
Apr 10, 2025
app pub date -
Oct 4, 2024
filing date -
Oct 4, 2024
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Abstract
A system and method for providing cardiac pulmonary nerve stimulation (CPNS) with therapy titration, a goodness indicator, and therapy weaning. Therapy titration can include using physiological measurements of contractility, lusitropy, and chronotropy to determine therapy efficacy and adjust therapy delivery. For example, the electrode position and stimulation intensity can be adjusted based on the physiological measurements. Therapy titration can include closed-loop therapy delivery, in which therapy is automatically adjusted based on the measured physiological parameters. A goodness indicator can be used to monitor cardiovascular parameters such as contractility, preload, lusitropy, systolic function, and/or chronotropy. The goodness indicator can determine whether the change in these parameters from nerve stimulation is positive, and further indicate optimal stimulation. Therapy weaning can include gradually reducing stimulation while ensuring no significant reduction in therapeutic efficacy ensues.
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