MASKED IL12 PROTEIN

Number of patents in Portfolio can not be more than 2000

United States of America

APP PUB NO 20250114489A1
SERIAL NO

18838513

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed herein are masked IL12 proteins that can be activated both in vitro and in vivo. Surprisingly, a small, bioorthogonal group is sufficient to deactivate or mask the IL12 protein, which can thereafter be activated by contacting the masked IL12 protein with the bioorthogonal reactive partner of the Trigger joining the IL12 protein to the mask (either a dienophile or a diene). The invention also relates to methods for using and preparing said masked IL12 proteins.

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Patent Owner(s)

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TAGWORKS PHARMACEUTICALS B V6525 ED NIJMEGEN

International Classification(s)

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  • 2023 Application Filing Year
  • A61K Class
  • 11803 Applications Filed
  • 2060 Patents Issued To-Date
  • 17.46 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DE, ROODE Kim Elisa Nijmegen, NL 1 0
DEN, BROK Martijn Hendrikus Martinus Gerardus Maria Nijmegen, NL 1 0
KLEIJN, Laurens Henri Johan Pittsburgh, US 4 0
ROBILLARD, Marc Stefan Eindhoven, NL 32 245
ROSSIN, Raffaella Eindhoven, NL 23 163
VERSTEEGEN, Ronny Mathieu Hegelsom, NL 23 154
WOUTERS, Lieke Willemijn Maria Nijmegen, NL 1 0
ZIJLMANS, Lucas Hendricus Maria Lent, NL 1 0

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges9747201 - 1005001000150020002500300035004000450050005500600065007000750080008500900095001000010500

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