Importance

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Abstract

Compositions and methods of improving radiation therapy are provided. The composition typically includes an effective amount of 7-DHC or a derivative or analog thereof. The methods typically include administering the composition to a subject in need thereof in combination with one or more doses of radiation therapy, preferably non-ultraviolet radiation therapy. A preferred radiation is ionizing radiation. The compositions and methods can be used to treat tumors, e.g., benign and malignant tumors. Thus, methods of treating cancer are provided. In preferred embodiments, the 7-DHC or a derivative or analog thereof is encapsulated or incorporated into nanoparticles. The particles can be, for example, polymeric nanoparticles, lipoprotein or lipoprotein-like particles, liposomes, inorganic nanoparticles, or a combination thereof. In some embodiments, the 7-DHC or analog thereof is derivatized with a polymer or saccharide, which is some embodiments, can self-assemble into particles. In some embodiments, the nanoparticles further include a targeting agent coupled thereto.

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First Claim