LAT ACTIVATING CHIMERIC ANTIGEN RECEPTOR T CELLS AND METHODS OF USE THEREOF
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United States of America
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Issued Date -
Apr 10, 2025
app pub date -
Aug 4, 2022
filing date -
Aug 4, 2022
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Abstract
The disclosure describes T cells that express chimeric antigen receptors (CARs), as well as pharmaceutical compositions comprising T cells and methods of making and using such T cells. Particularly, this disclosure describes T cells expressing a first CAR that binds to a first antigen and a second CAR comprising a LAT intracellular signaling domain that binds to a second antigen, and methods of use in treating cancers, such as solid tumors and hematological malignancies.
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