LIPOSOMAL FORMULATION FOR JOINT LUBRICATION
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United States of America
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Issued Date -
Apr 10, 2025
app pub date -
Dec 17, 2024
filing date -
Dec 17, 2024
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Abstract
The present invention provides a pharmaceutical composition for the lubrication of joints, with the pharmaceutical composition including a non-ionic tonicity agent of a polyol such as mannitol, and liposomes having a membrane that includes at least a phospholipid selected from the group consisting of dimyristoylphosphatidylcholine (DMPC); a mixture of DMPC and dipalmitoyl-phosphatidylcholine (DPPC); a mixture of DMPC and 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC); a mixture of DMPC and N-palmitoyl-D-erythro-sphingosy lphosphorylcholine (D-erythro C16); and a mixture of DMPC and 1,2-dipentadecanoyl-sn-glycero-3-phosphocholine (C-15); wherein the pharmaceutical composition is essentially free of hyaluronic acid and any additional pharmaceutically active agents, wherein the at least one membrane has a phase transition temperature in the range of about 20° C. to about 39° C., and the joint has a joint temperature which is above the phase transition temperature.
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