HIGH MOLECULAR WEIGHT MODIFIED RNA COMPOSITIONS
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United States of America
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Apr 10, 2025
app pub date -
Nov 14, 2024
filing date -
Nov 14, 2024
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Abstract
Post-transcriptionally chemically modified double strand RNAs (MdsRNAs) and post-transcriptionally chemically modified RNAs (MRNAs) having a high molecular weight polyalkyloxy modification at the 2′-OH position are described. This modification allows for greater bioavailability of the compound, better stability of the compound, and allows for greater stability against nucleases. The MdsRNAs and MRNAs can be economically produced in a readily scalable manner. Compositions of MdsRNAs and MRNAs having chemically modified nucleotides are described, such that the MdsRNAs and MRNAs are modified to contain high molecular weight polyalkyloxy polymers. Synthetic methods for efficiently making these MdsRNAs and MRNAs and methods of using MdsRNAs and MRNAs are described.
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