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GLOBALFOUNDRIES U S INC	400 STONEBREAK ROAD EXTENSION MALTA NY 12020

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• H03F:AMPLIFIERS

• 2023 Application Filing Year
• H03F Class
• 980 Applications Filed
• 177 Patents Issued To-Date
• 18.07 % Issued To-Date

Inventor(s)

Inventor Name	Address	# of filed Patents	Total Citations
Bellaouar, Abdellatif	Richardson, US	91	933
# of filed Patents : 91 Total Citations : 933
Syed, Shafiullah	Murphy, US	31	201
# of filed Patents : 31 Total Citations : 201

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Full Text

US Patent Application No: 2013/0281,513

siRNA FOR INHIBITION OF Hif1alpha EXPRESSION AND ANTICANCER COMPOSITION CONTAINING THE SAME

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Abstract

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Disclosed are small interfering RNA (siRNA) that complementarily binds to a base sequence of Hif1α mRNA transcript, thereby inhibiting expression of Hif1α without inducing immune responses, and a use of the siRNA for prevention and/or treatment of cancer. Since Hif1α is commonly overexpressed in almost all cancer cells, the siRNA that complementarily binds to Hif1α-encoding mRNA may inhibit expression of Hif1α through RNA-mediated interference (RNAi), thereby inhibiting proliferation and metastasis of cancer cells, and thus, the siRNA may be useful as an anticancer agent.

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Description

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