METHODS FOR DESCRIBING VAGINAL MICROBIOMES AND USE OF THE SAME IN PROGNOSTIC, DIAGNOSTIC, AND THERAPEUTIC STRATEGIES FOR BACTERIAL VAGINOSIS
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United States of America
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Issued Date -
Apr 3, 2025
app pub date -
Oct 2, 2024
filing date -
Oct 2, 2024
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Abstract
A Lactobacillus-dominated vaginal microbiome provides the first line of defense against numerous adverse genital tract health outcomes. However, there is limited understanding of the mechanisms by which the vaginal microbiome modulates protection. Metagenomic community state types (mgCSTs), which uses metagenomic sequences to describe and define vaginal microbiomes based on both composition and function are described herein, along with their use in prognostic, diagnostic and therapeutic applications against bacterial vaginosis.
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