EX VIVO PROTEASE ACTIVATION AND DETECTION
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United States of America
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Issued Date -
Apr 3, 2025
app pub date -
Oct 28, 2022
filing date -
Oct 28, 2022
priority date (Note) -
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Abstract
The present application provides methods for contacting a body fluid sample from a subject with a molecule ex vivo. The method comprises contacting a body fluid with a molecule comprising a reporter thereof and the reporter is cleaved by an agent in the body fluid. An additional ingredient is added to the body fluid sample, and the rate of formation or the amount of the cleaved reporter is higher compared to a sample without addition of the ingredient. Diseases and conditions that can be determined by the method are also described.
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