HUMAN ORGAN-ON-A-CHIP HAVING REVERSE MICRO-WEIR STRUCTURE AND USES THEREOF
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United States of America
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Apr 3, 2025
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Jan 16, 2023
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Jan 16, 2023
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Abstract
The present invention relates to an organ-on-a-chip having a reverse micro-weir structure and uses thereof. Using the organ-on-a-chip for evaluating drug efficacy and toxicity provided by the present invention makes it possible to overcome the limitations of conventional two-dimensional in-vitro cell culture methods that cannot mimic the human microenvironment and the inaccuracies due to differences between species in animal testing, and to derive more accurate efficacy and toxicity results for cells treated with drugs. Accordingly, as the organ-on-a-chip of the present invention is used as an alternative test method to animal testing, the organ-on-a-chip can drastically reduce the cost and time required for new drug development and drug screening and can also be effectively used to conduct research on the cellular microenvironment, other organ-on-a-chips, and drug metabolism mechanisms and to develop new drugs.
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